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bioRxiv · 10.64898/2026.08.19.745716

Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment

Srivastav, S.·Chaudhari, P. R.·Suryavanshi, S.·Pange, N.·Vaidya, V. A.·Anand, A.
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Abstract

Early life stress (ELS) in the form of adverse experiences in childhood results in multiple psycho-physiological pathologies during adulthood and accelerates aging. Such pathologies are recently observed to be alleviated upon nicotinamide treatment in a maternal separation model of ELS. We report a nicotinamide-driven amelioration of gut dysbiosis in middle-aged rodents with a history of neonatal maternal separation.

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Srivastav, S., Chaudhari, P. R., Suryavanshi, S., Pange, N., Vaidya, V. A., Anand, A.. 2026-08-21. Early-life stress-induced gut dysbiosis is ameliorated by nicotinamide treatment. https://doi.org/10.64898/2026.08.19.745716

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