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bioRxiv · 10.64898/2026.08.12.742892

Synchrotron phase contrast micro-CT of prostate tissue

Abstract

Formalin-fixed prostate tissue samples were imaged by propagation-based synchrotron phase contrast micro computed tomography ({micro}CT) with a 3D spatial resolution of ca. 3 {micro}m. Post-{micro}CT, samples were prepared for histology with sections close to coplanar with the transverse {micro}CT image planes. Haematoxylin and eosin stained sections were examined by an expert prostate histopathologist and compared qualitatively with corresponding {micro}CT-visible microstructure features. There is potential for {micro}CT to provide complimentary information to conventional histology and light microscopy without the need for preparation of stained thin sections. For the imaging conditions and spatial resolution of our study, {micro}CT may provide tissue architectural features similar to those used in Gleason grading, albeit without clear subcellular microstructure detail. At the spatial resolution of our study {micro}CT may provide novel 3D microstructure information for validation of diffusion weighted magnetic resonance imaging (MRI) methods. As an example, we demonstrate a qualitative correlation between {micro}CT-derived stromal fibre orientation and preferential water diffusion direction measured by diffusion tensor MRI microscopy of the same sample.

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Bourne, R. M., Arhatari, B., Watson, G., Gureyev, T., Phipps, A., Dowland, S., Kurniawan, N. D., Sved, P.. 2026-08-17. Synchrotron phase contrast micro-CT of prostate tissue. https://doi.org/10.64898/2026.08.12.742892

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