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bioRxiv · 10.64898/2026.07.15.738771

Circadian rhythm disruption alters rhythmic properties of clock and memory gene expression in the hippocampi of rats

Deibel, S. H.·Lehr, A. B.·Michalopoulou, S.·Husain, I.·Fornasiero, E. F.·Bye, C.·Hong, N.·Kovalchuk, O.·McDonald, R.
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Abstract

Our modern environment - with its artificial lighting, irregular work hours, and frequent travel -- often disrupts our circadian rhythms, which can lead to health problems, particularly in learning and memory. This is especially concerning given the aging population and the rising prevalence of dementia. Yet, the biological mechanisms linking circadian disruption to cognitive impairment remain poorly understood. At the molecular level, genetic techniques have been used to attenuate or abolish expression of key genes involved in circadian rhythms and these manipulations have detrimental effects on memory function. However, whether environmentally induced circadian disruption, impairs memory via changes in overall gene expression levels in the hippocampus or rather via changes in the coordinated rhythmic patterns of circadian expression across groups of genes is less known. Here, we examined how environmental circadian disruption affects the expression of genes involved in the circadian clock and memory in the hippocampus of rats using a forced desynchrony model. Circadian disruption changed the rhythmic properties of gene expression in most genes assessed but had no measurable effect on average expression levels across the day. These findings suggest that the inability to maintain circadian synchrony rather than overall expression may underlie the cognitive deficits observed in circadian-related disorders.

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Deibel, S. H., Lehr, A. B., Michalopoulou, S., Husain, I., Fornasiero, E. F., Bye, C., Hong, N., Kovalchuk, O., McDonald, R.. 2026-07-21. Circadian rhythm disruption alters rhythmic properties of clock and memory gene expression in the hippocampi of rats. https://doi.org/10.64898/2026.07.15.738771

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