CORe Designer: a CRISPR design tool for proteome engineering

Das, A.; Grech, J.; Hung, S.; Wu, J.; Callafe, C.; Corrie, A.; Yeung, K.; Goodwin, I.; Yu, D.; Hassan, S.; Reid, K.; Storch, M.; Child, M. A.

doi:10.64898/2026.06.12.731864

bioRxiv · 10.64898/2026.06.12.731864

CORe Designer: a CRISPR design tool for proteome engineering

Das, A.·Grech, J.·Hung, S.·Wu, J.·Callafe, C.·Corrie, A.·Yeung, K.·Goodwin, I.·Yu, D.·Hassan, S.·Reid, K.·Storch, M.·Child, M. A.

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Abstract

Precision proteome engineering requires tools that leverage CRISPR technologies, yet most current design platforms remain gene-centric. To bridge this gap, we introduce CORe Designer. Featuring an intuitive graphical user interface, CORe Designer enables researchers to design guide RNAs and homology-directed repair templates in a protein-centric manner. By automating these workflows, CORe Designer enables the design of targeted mutagenesis experiments for precision proteome engineering to be completed in minutes.

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Das, A., Grech, J., Hung, S., Wu, J., Callafe, C., Corrie, A., Yeung, K., Goodwin, I., Yu, D., Hassan, S., Reid, K., Storch, M., Child, M. A.. 2026-06-12. CORe Designer: a CRISPR design tool for proteome engineering. https://doi.org/10.64898/2026.06.12.731864

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