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bioRxiv · 10.64898/2026.06.11.731524

The old pipe gives the sweetest smoke: A phylogenetic turn for eDNA metabarcoding

Abstract

Environmental DNA (eDNA) metabarcoding has transformed biodiversity monitoring, yet most analyses rely on taxonomic metrics that are sensitive to methodological variation and limit cross-study comparability. We propose a "phylogenetic turn" in eDNA analysis through the integration of phylogenetic diversity (PD) metrics. By incorporating evolutionary relationships, PD reduces dependence on species-level resolution, increases robustness to detection biases, and better captures the evolutionary "option value" of biodiversity. We synthesize key PD metrics across richness, divergence, and regularity, emphasizing the use of standardized effect sizes (SES) for ecological interpretation while addressing challenges in metric selection. We apply this framework to five marine eDNA datasets (2021-2025) spanning ecologically and geographically contrasting ecosystems, from tropical to Arctic regions, and encompassing a wide gradient of anthropogenic pressure. Across datasets, we identify consistent patterns: anthropized ecosystems exhibit high taxonomic richness but reduced phylogenetic diversity, indicating phylogenetic clustering, whereas less disturbed systems show lower richness but greater evolutionary breadth. These findings demonstrate that PD reveals ecological structure not captured by taxonomic metrics, including signatures of environmental filtering and community assembly processes. By providing a reproducible analytical workflow based on standardized eDNA datasets, we position phylogenetic diversity as a critical bridge between eDNA data and conservation frameworks. Ultimately, eDNA-based phylogenetic approaches open new avenues for decoding global biodiversity patterns across heterogeneous ecosystems.

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BibTeXRIS

Haderle, R., Ung, V., Jung, J.-L.. 2026-06-15. The old pipe gives the sweetest smoke: A phylogenetic turn for eDNA metabarcoding. https://doi.org/10.64898/2026.06.11.731524

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