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bioRxiv · 10.64898/2026.05.18.726121

UT-018 Accelerates Wound Repair and Hair Follicle Regeneration in Murine Models

Saxena, U.·K, S.·Jadhav, P.·Shahapur, S.·Mehboob, S.·Kadiyala, G.·Gorantla, M.
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Abstract

UT-018, a stem cell chemoattractant formulation, demonstrated significant regenerative activity across independent murine wound-healing and hair-regeneration studies. Topical treatment accelerated wound closure, enhanced granulation tissue formation, improved collagen organization, increased fibroblast proliferation, and enhanced dermal vascularization. Separate hair-growth studies demonstrated increased follicular density, deeper follicular penetration, enhanced dermal vascularization, and induction of anagen-phase transition by UT-018. Mechanistic studies demonstrated strong intracellular cAMP generation and activation-associated {beta}-catenin phosphorylation consistent with GPCR-mediated regenerative signaling.

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Saxena, U., K, S., Jadhav, P., Shahapur, S., Mehboob, S., Kadiyala, G., Gorantla, M.. 2026-05-21. UT-018 Accelerates Wound Repair and Hair Follicle Regeneration in Murine Models. https://doi.org/10.64898/2026.05.18.726121

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