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bioRxiv · 10.64898/2026.05.18.724202

Toward CT-based Tractography: Presurgical White Matter Tract Mapping in Intracerebral Hemorrhage

Huang, G.·Xie, G.·Li, Y.·Wang, Q.·Yao, S.·Tan, Y.·Kikinis, R.·Golby, A. J.·O'Donnell, L. J.·Zhang, F.
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Abstract

Presurgical mapping of key white matter (WM) fiber tracts is crucial for intracerebral hemorrhage (ICH) surgery, but it currently relies on tractography from diffusion MRI (dMRI), which has limited applicability in urgent or resource-constrained settings due to long scan times and limited MRI availability. To bridge this gap, we developed a deep learning approach designed to reconstruct critical fiber tracts directly from routinely acquired CT scans, focusing on the corticospinal tract (CST) due to its high clinical relevance. By training a novel network on a curated dataset of 150 paired CT-dMRI scans (101 ICH patients and 49 healthy subjects), we enabled the direct mapping of the CST from CT images alone, bypassing the traditional requirement for dMRI. Our results demonstrate that the CT-derived tracts achieve high anatomical plausibility, with neurosurgeon expert assessments yielding a Likert score of 3.64. Furthermore, the clinical relevance of these reconstructions was validated by a significant correlation between CT-derived tract integrity and patient motor scores (r = 0.726, p = 3.731x 10-7). These findings suggest that in complex clinical scenarios, particularly where dMRI signal quality is compromised by lesion-induced distortion, this CT-based mapping may serve as a useful anatomical reference. Overall, by enabling CT-based WM mapping, our method potentially offers a practical route to gain the key advantages of tractography in resource-limited or time-critical settings

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Huang, G., Xie, G., Li, Y., Wang, Q., Yao, S., Tan, Y., Kikinis, R., Golby, A. J., O'Donnell, L. J., Zhang, F.. 2026-05-21. Toward CT-based Tractography: Presurgical White Matter Tract Mapping in Intracerebral Hemorrhage. https://doi.org/10.64898/2026.05.18.724202

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