Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease

Yang, L.; Zhang, J.; Wang, J.; Huang, H.-H.; Han, H.; Razansky, D.; Alzheimer's Disease Neuroimaging Initiative,; Rominger, A.; Lu, J.; Ni, R.

doi:10.64898/2026.05.14.725296

bioRxiv · 10.64898/2026.05.14.725296

Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease

Yang, L.·Zhang, J.·Wang, J.·Huang, H.-H.·Han, H.·Razansky, D.·Alzheimer's Disease Neuroimaging Initiative,·Rominger, A.·Lu, J.·Ni, R.

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Abstract

Brain stimulation is increasingly recognized as an effective and important therapeutic intervention for many brain diseases. Distance between the scalp and other brain regions is a pivotal variable for neurostimulation planning and the development of new techniques, but alterations in the distance between the scalp and other regions in brain diseases are largely unknown. In this study, we developed an automatic pipeline to calculate scalp-to-region distance (SRD) values from T1 MR images and applied it to a total of 1382 participants, including patients with autism spectrum disorder (ASD), Parkinsons disease (PD), Alzheimers disease (AD), and cognitively normal controls (CNs). Cloud points were uniformly sampled on the automatically extracted scalp surface and cortex surface, on which the point-wise distance maps were generated. The brain was then coregistered with the BCI-DNI atlas, and SRD value for each brain region was extracted. Analysis of covariance (ANCOVA) was performed for SRD in each brain region, with age and sex as covariates. Compared with CNs, ASD patients showed widespread SRD decreases across the brain with prominent involvement of the frontal lobe, especially the orbitofrontal cortex and adjacent regions. In contrast, in AD patients, significantly increased SRD values were observed in various regions of the frontal gyrus. No significant SRD alteration was found in PD patients after correction. The automatic SRD calculation pipeline and the different patterns of SRD alterations in these diseases might be helpful for future neurostimulation planning in clinical practice. HighlightsO_LIAutomatic pipeline enables scalp-to-region distance (SRD) measurement, facilitates brain stimulation planning. C_LIO_LIASD patients show widespread SRD decreases, especially in the orbitofrontal cortex and adjacent regions. C_LIO_LIAD patients present increased SRD in the frontal gyrus and decreased SRD in the parahippocampal gyrus. C_LI

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Yang, L., Zhang, J., Wang, J., Huang, H.-H., Han, H., Razansky, D., Alzheimer's Disease Neuroimaging Initiative,, Rominger, A., Lu, J., Ni, R.. 2026-05-18. Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease. https://doi.org/10.64898/2026.05.14.725296

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