In vivo modulation of locus coeruleus activity by light

Balda, F.; Sharifpour, R.; Campbell, I.; Beckers, E.; Letot, S.; Berger, A.; Mortazavi, N.; Koshmanova, E.; Collette, F.; Lamalle, L.; Jacobs, H.; Zubkov, M.; Talwar, P.; Vandewalle, G.

doi:10.64898/2026.04.28.721313

bioRxiv · 10.64898/2026.04.28.721313

In vivo modulation of locus coeruleus activity by light

Balda, F.·Sharifpour, R.·Campbell, I.·Beckers, E.·Letot, S.·Berger, A.·Mortazavi, N.·Koshmanova, E.·Collette, F.·Lamalle, L.·Jacobs, H.·Zubkov, M.·Talwar, P.·Vandewalle, G.

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Abstract

Dysfunction of the Locus coeruleus (LC), a small brainstem nucleus which consists of the brains primary source of norepinephrine, is linked to various neurological and psychiatric disorders. Light exposure influences many non-image-forming (NIF) biological functions including those modulated by LC activity. Yet direct evidence of light-driven modulation of the LC has remained elusive due to the structures small size and deep location. Using ultra-high-field (7 Tesla) functional MRI during an emotional task under varying illuminances, we demonstrate that light modulates LC activity in an emotion-dependent manner. We show that increased illuminance dampens LC responses to negative emotional stimuli while enhancing responses to neutral stimuli. Furthermore, we provide tentative evidence that within an emotional context, light may affect LC activity through the basomedial nucleus of the amygdala as well as through a region of the hypothalamus encompassing the lateral hypothalamus. These findings open avenues for the development of targeted, non-pharmacological treatments leveraging light to modulate norepinephrine tone and/or LC activity in several neuropsychiatric disorders. Significance StatementDysfunction of the Locus Coeruleus (LC), a small nucleus of brain and the main source of norepinephrine, is linked to various brain disorders. Here we provide in vivo evidence that exposure to light can alter the activity of the LC with higher illuminance leading to dampened LC responses to negative emotional stimuli. These findings identify the LC as a key target for the therapeutic effects of light on emotion, offering a biological framework for using light to treat neuropsychiatric disorders.

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Balda, F., Sharifpour, R., Campbell, I., Beckers, E., Letot, S., Berger, A., Mortazavi, N., Koshmanova, E., Collette, F., Lamalle, L., Jacobs, H., Zubkov, M., Talwar, P., Vandewalle, G.. 2026-04-30. In vivo modulation of locus coeruleus activity by light. https://doi.org/10.64898/2026.04.28.721313

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