Food preference is associated with distinct large-scale cortical functional connectivity patterns during food-image observation

Abstract

Food preference influences behavior toward food-related stimuli, yet the large-scale neural mechanisms underlying this process remain unclear. This study investigated whether preferred and nonpreferred food cues are associated with distinct patterns of cortical functional connectivity during the observation of food images. Data from 25 of the 40 recruited healthy adults were included in the final analysis after excluding individuals with highly unbalanced response tendencies. Participants viewed 150 food images and rated each image on a four-point preference scale. Trials were classified as favorite food (FF) or disliked food (DF). High-density electroencephalography (EEG) was recorded during the task, and source-level ROI-to-ROI functional connectivity was analyzed using amplitude envelope correlation in the alpha (8-13 Hz) and beta (13-25 Hz) frequency bands over the 1000-ms period after food-picture onset. Response time did not differ significantly between FF and DF trials. However, distinct functional connectivity patterns were observed between conditions in both frequency bands. In the alpha band, FF trials involved a network including the cuneus, parietal regions, cingulate regions, and lateral occipital cortex, whereas DF trials involved the isthmus cingulate, caudal middle frontal gyrus, inferior temporal cortex, superior parietal lobule, and lateral occipital cortex. In the beta band, FF trials involved the isthmus cingulate, precuneus, parietal regions, and pericalcarine cortex, whereas DF trials additionally involved frontal regions, including the superior frontal gyrus and pars triangularis. These findings indicate that food preference is associated with distinct large-scale cortical functional connectivity patterns during food image observation, suggesting differential neural processing of preferred and nonpreferred food cues.