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bioRxiv · 10.64898/2026.04.12.718071

A Brain-wide Neuronal Spiking and Behavior Dataset for Working Memory-Specific Activation and Reactivation in Mice

Huang, E.·Xu, D.·Zhu, H.·Chen, Z.·Li, P.·Chen, Y.·Lei, S.·Liu, J.·Li, C.·Zhang, X.
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Abstract

AbstractHow do millisecond-scale neural activities mediate multi-second behaviors such as working memory? This dataset provides brain-wide, high-spatiotemporal-resolution single-unit spiking activity recorded from 40 head-fixed mice performing an olfactory delayed paired-association (ODPA) task, encompassing 33,028 neurons across 62 anatomically defined brain regions. Utilizing this dataset enables the extraction of millisecond-scale within- and cross-region spike couplings enriched among memory-content-selective neurons. These couplings may be used to identify higher-order, hierarchically structured activity motifs. Because these multi-neuron patterns are captured both during active task performance and spontaneous inter-trial intervals, this dataset provides a resource for studying replay-related activity and for testing hypotheses about circuit-level processes associated with perceptual working memory. The dataset supports broad investigations into cross-regional spike organization, functional coupling, and temporal coding in working memory circuits.

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Huang, E., Xu, D., Zhu, H., Chen, Z., Li, P., Chen, Y., Lei, S., Liu, J., Li, C., Zhang, X.. 2026-04-15. A Brain-wide Neuronal Spiking and Behavior Dataset for Working Memory-Specific Activation and Reactivation in Mice. https://doi.org/10.64898/2026.04.12.718071

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