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bioRxiv · 10.64898/2026.03.26.714547

Reticulospinal Tract Hyperexcitability in the Upper Limb After Stroke is Associated with Motor Impairment and Not with Functional Compensation

Lorber-Haddad, A.·Goldhammer, N.·Mizrahi, T.·Handelzalts, S.·Shmuelof, L.
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Abstract

BackgroundAccumulating results suggest that reticulospinal tract (RST) excitability increases after stroke. While animal studies suggest this hyperexcitability may compensate for corticospinal tract (CST) damage, its role in motor function in people with stroke (PwS) remains debated. This study aimed to: (1) replicate findings of RST hyperexcitability in PwS using the StartReact paradigm, measuring acceleration of motor response to a startling auditory stimulus; (2) examine the relationship between RST hyperexcitability and motor impairments after stroke; and (3) explore whether RST hyperexcitability provides functional benefits in severely impaired PwS. MethodsForty-six PwS completed the StartReact paradigm and motor assessments (Fugl-Meyer, ARAT, grip strength, Modified Ashworth Scale). PwS were categorized into high StartReact effect and typical StartReact effect subgroups based on comparisons with a healthy control group (n=37). Severe impairment was defined as ARAT [≤]10. ResultsPwS exhibited significantly greater StartReact effects than controls. The high StartReact effect subgroup showed worse motor function, weaker grip strength, and higher spasticity. Among severely impaired PwS, high StartReact effect was not associated with improved grip strength. ConclusionsThese findings confirm the existence of RST hyperexcitability after stroke and suggest it is associated with poorer motor outcomes, likely due to reduced cortical input to the brainstem. The absence of functional benefit in severely impaired individuals supports the interpretation that RST hyperexcitability is a maladaptive rather than a compensatory reaction to brain damage. These findings provide insight into the neurophysiological mechanisms underlying motor impairments after stroke and do no imply direct clinical or therapeutic applications.

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Lorber-Haddad, A., Goldhammer, N., Mizrahi, T., Handelzalts, S., Shmuelof, L.. 2026-03-30. Reticulospinal Tract Hyperexcitability in the Upper Limb After Stroke is Associated with Motor Impairment and Not with Functional Compensation. https://doi.org/10.64898/2026.03.26.714547

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