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bioRxiv · 10.64898/2026.03.19.713030

TogoMCP: Natural Language Querying of Life-Science Knowledge Graphs via Schema-Guided LLMs and the Model Context Protocol

Kinjo, A. R.·Yamamoto, Y.·Bustamante-Larriet, S.·Labra-Gayo, J. E.·Fujisawa, T.
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Abstract

Querying the RDF Portal knowledge graph maintained by DBCLS--which aggregates approximately 60 life-science databases--requires proficiency in both SPARQL and database-specific RDF schemas, placing this resource beyond the reach of most researchers. Large Language Models (LLMs) can, in principle, translate natural-language questions into executable SPARQL, but without schema-level context, they frequently fabricate non-existent predicates or fail to resolve entity names to database-specific identifiers. We present TogoMCP, a system that recasts the LLM as a protocol-driven inference engine orchestrating specialized tools via the Model Context Protocol (MCP). Two mechanisms are essential to its design: (i) the MIE (Metadata-Interoperability-Exchange) file, a concise YAML document that dynamically supplies the LLM with each target databases structural and semantic context at query time; and (ii) a two-stage workflow separating entity resolution via external REST APIs from schema-guided SPARQL generation. On a benchmark of 50 biologically grounded questions spanning five types and 23 databases, TogoMCP achieved a large improvement over an unaided baseline (Cohens d = 1.82, Wilcoxon p < 0.001), with win rates exceeding 80% for question types with precise, verifiable answers. An ablation study shows that all component configurations deliver significant improvements, with MIE schema files providing the largest marginal contribution on mean per-question score ({Delta} = +0.50 relative to a no-MIE condition, two-sided Wilcoxon p = 0.067; 90% bootstrap CI [+0.04, +0.94] excludes zero); a one-line instruction to load the relevant MIE file recovers the same mean improvement as a full procedural protocol, while the protocol additionally reduces downside risk (loss rate 1.6% vs. 4.8%, Fisher p = 0.036). These results suggest a general design principle: concise, dynamically delivered schema context is more valuable than complex orchestration logic for mean-score performance, while procedural guidance plays a complementary role in narrowing variance. Database URL: https://togomcp.rdfportal.org/

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Kinjo, A. R., Yamamoto, Y., Bustamante-Larriet, S., Labra-Gayo, J. E., Fujisawa, T.. 2026-03-23. TogoMCP: Natural Language Querying of Life-Science Knowledge Graphs via Schema-Guided LLMs and the Model Context Protocol. https://doi.org/10.64898/2026.03.19.713030

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