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bioRxiv · 10.64898/2026.03.06.710126

Benchmarking 80 binary phenotypes from the openSNP dataset using deep learning algorithms and polygenic risk score tools

Abstract

Genotype-phenotype prediction plays a crucial role in identifying disease-causing single nucleotide polymorphisms and precision medicine. In this manuscript, we benchmark the performance of various machine/deep learning algorithms and polygenic risk score tools on 80 binary phenotypes extracted from the openSNP dataset. After cleaning and extraction, the genotype data for each phenotype is passed to PLINK for quality control, after which it is transformed separately for each of the considered tools/algorithms. To compute polygenic risk scores, we used the quality control measures for the test data and the genome-wide association studies summary statistic file, along with various combinations of clumping and pruning. For the machine learning algorithms, we used p-value thresholding on the training data to select the single nucleotide polymorphisms, and the resulting data was passed to the algorithm. Our results report the average 5-fold Area Under the Curve (AUC) for 29 machine learning algorithms, 80 deep learning algorithms, and 3 polygenic risk scores tools with 675 different clumping and pruning parameters. Machine learning outperformed for 44 phenotypes, while polygenic risk score tools excelled for 36 phenotypes. The results give us valuable insights into which techniques tend to perform better for certain phenotypes compared to more traditional polygenic risk scores tools.

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BibTeXRIS

Muneeb, M. -, Ascher, D., Myung, Y., Feng, S., Henschel, A.. 2026-03-09. Benchmarking 80 binary phenotypes from the openSNP dataset using deep learning algorithms and polygenic risk score tools. https://doi.org/10.64898/2026.03.06.710126

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