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bioRxiv · 10.64898/2026.03.03.709421

No evidence for sleep-dependent memory generalization in a large online sample

Abstract

Memory generalization allows individuals to extract and apply information from prior experiences to novel situations, supporting flexible learning and efficient decision-making. Theoretical models suggest that sleep should facilitate generalization, yet the literature examining its role in promoting generalization is mixed. We recruited 137 participants via Prolific to complete an image-location memory task over two sessions spaced 12 hours apart. Participants were randomly assigned to the Wake group (learning in the morning) or the Sleep group (learning in the evening). In Session 1, participants learned the location of stimuli on the screen and were tested on their memory five minutes later. Twelve hours later, in Session 2, they were tested on their memory again. Stimuli consisted of 160 images from eight semantic categories and were strategically positioned on-screen to test the effects of generalization on retrieval (i.e., category-based memory distortions and biases). After the delay, retrieval was less accurate and demonstrated more generalization. However, these effects were mostly independent of Group, with some evidence for enhanced generalization following a period of wakefulness over sleep. Generalization was also driven by time of day, with more generalization in the evening relative to the morning. Taken together, our results, based on a large online sample, do not support a role for sleep in promoting memory generalization. Significance StatementBehavior is often guided by memories of previous experiences. However, for behavior to be adaptive and flexible (e.g., when encountering never-before-seen stimuli), regularities about the world must be extracted from these memories. This process, termed memory generalization, has been hypothesized to rely on sleep. We used a large online sample to test sleeps role in generalization and found no support for this hypothesis. Our results suggest that sleep and wakefulness contribute to generalization equally, with the latter potentially having a larger contribution.

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BibTeXRIS

Lu, T., Ji, Z., Tompary, A., Schechtman, E.. 2026-03-05. No evidence for sleep-dependent memory generalization in a large online sample. https://doi.org/10.64898/2026.03.03.709421

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