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bioRxiv · 10.64898/2026.02.24.707621

Cognitive control networks in human and macaque

Abstract

A much-replicated finding in human brain imaging is a distributed 'multiple-demand' or MD system, increasing in activity for many kinds of cognitive demand, and centrally involved in cognitive control. MD regions are proposed to encode a distributed mental model of critical task events, bound together in the roles and relationships needed to direct action selection. Though previous data hint at a corresponding network in the macaque, there has been no direct comparison to human data. Here we used functional magnetic resonance imaging to measure whole brain activation in a multi-step saccadic maze task, compared to a control requiring similar moves but without goal-based decisions. Human data were a close match to the canonical MD network, extended to include adjacent regions and in particular much of the canonical dorsal attention network. Data from two monkeys suggested correspondences in dorsomedial frontal, insula/orbitofrontal and posterior temporal cortex. In lateral frontal cortex there was just a single, largely dorsal activation patch, in contrast to multiple distinct human patches. In one animal, as in human, there was accompanying activation of dorsal and medial parietal cortex. In macaque as in human, together with previous data, our findings suggest an extended and strongly interconnected brain network recruited by increased cognitive challenge.

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BibTeXRIS

Mione, V., Kristensen, F. H., Assem, M., Schuffelgen, U., Kyllingsbaek, S., Buckley, M., Mitchell, D. J., Duncan, J.. 2026-02-25. Cognitive control networks in human and macaque. https://doi.org/10.64898/2026.02.24.707621

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