LLM-PathwayCurator transforms enrichment terms into audit-gated decision-grade claims

Furudate, K.; Takahashi, K.

doi:10.64898/2026.02.18.706381

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bioRxiv · 10.64898/2026.02.18.706381

LLM-PathwayCurator transforms enrichment terms into audit-gated decision-grade claims

Furudate, K.·Takahashi, K.

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Abstract

Pathway enrichment of omics data requires careful interpretation, and LLM-PathwayCurator transforms enrichment outputs into auditable, evidence-linked claims with redundancy-highlighting module mapping. Across seven cohorts from The Cancer Genome Atlas (TCGA), it achieved qualified coverage of 0.66 to 0.80 but fell to a range of 0.20 to 0.42 under context swap and 0.20 to 0.30 after supporting-gene dropout due to contract violations or weak gene support. LLM-PathwayCurator generates decision-grade claims with audit-gated abstention to establish a reproducible quality-assurance layer for omics interpretation.

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Furudate, K., Takahashi, K.. 2026-02-19. LLM-PathwayCurator transforms enrichment terms into audit-gated decision-grade claims. https://doi.org/10.64898/2026.02.18.706381

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