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bioRxiv · 10.64898/2026.02.10.705020

GeneReL: A Large Language Model-Powered Platform for Gene Regulatory Relationship Extraction with Community Curation

Park, J.-S.·Ha, S.·Lee, Y.·Kang, Y. J.
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Abstract

MotivationGene regulatory networks provide fundamental insights into plant biology, yet extracting structured interaction data from scientific literature remains a significant bottleneck. Traditional manual curation cannot scale to meet the demands of modern research, while automated text mining approaches struggle with the complexity of gene nomenclature and relationship classification. Large language models offer promising capabilities for information extraction, but integrated platforms combining LLM extraction with community validation for plant regulatory databases remain scarce. ResultsWe developed GeneReL, an integrated platform combining LLM-based extraction with community-driven curation for gene regulatory networks in Arabidopsis thaliana. The system employs a tiered pipeline using Claude Haiku 4.5 for screening, Claude Sonnet 4 for extraction, and Claude Opus 4 for verification, along with a novel five-step gene normalization pipeline incorporating paper-text search and LLM-based disambiguation with UniProt annotations. The database contains 13,710 curated interactions across 51 relationship types, with 90.2% classified as high confidence based on linguistic certainty markers in source text. Comparison with IntAct reveals 86.8% of interactions are unique to our literature-derived database, demonstrating complementary coverage to existing resources. The web platform provides card-based browsing with voting capabilities, interactive network visualization using Cytoscape.js with locus-ID-based node consolidation, and administrative interfaces for curator review of ambiguous gene mappings. Availability and ImplementationGeneReL is freely accessible at https://generel.newgenes.me. Contactkangyangjae@gnu.ac.kr

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Park, J.-S., Ha, S., Lee, Y., Kang, Y. J.. 2026-02-11. GeneReL: A Large Language Model-Powered Platform for Gene Regulatory Relationship Extraction with Community Curation. https://doi.org/10.64898/2026.02.10.705020

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