bioRxiv · 10.64898/2025.12.24.696143
A Hybridization-Based Novel DNA Storage Technology with Rapid Read Performance
Abstract
The development of traditional silicon-based microelectronic storage media has increasingly lagged behind the rapidly growing demands of contemporary data storage. DNA storage, with its ultra-high information density and long-term preservation advantages, has rapidly become a research hotspot for next-generation storage technologies. However, current mainstream DNA storage methods based on synthesis and sequencing suffer from slow read/write speeds, hindering practical applications. To address this limitation, we propose an innovative hybridization-based DNA storage scheme. Through principle validation experiments, short-text read/write and error-correction tests, and high-density multi-format file storage experiments, we verify the feasibility of this approach. The proposed method exhibits high parallelism, rapid read speeds, and robust encryption capabilities, demonstrating promising application prospects in scenarios such as confidential data storage.
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Zhang, Y., Jia, L., Wang, X., Shi, Y., Wang, H., Zhang, D., Cheng, P., Zhao, Y., Xu, M., Zhang, X., Xiao, Z., Wu, L., Zhou, X., Liu, D.. 2025-12-25. A Hybridization-Based Novel DNA Storage Technology with Rapid Read Performance. https://doi.org/10.64898/2025.12.24.696143
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