Search bioRxiv⌕ Search

bioRxiv · 10.64898/2025.12.19.695393

Material perception relies on context-dependent active sensing strategies

Abstract

Material perception is typically studied under passive and highly constrained viewing conditions, thus leaving it unclear whether humans rely on active sampling strategies to resolve perceptual ambiguities. In everyday vision, however, observers naturally move their heads and manipulate objects with their hands to obtain informative cues, thus raising the question of how such exploratory actions contribute to material recognition. We used immersive virtual reality to examine whether viewpoint changes and object manipulations support the discrimination of visually challenging materials, specifically metal versus glass, whose appearances depend strongly on the associated illumination and viewing geometry. On the basis of three experiments, we revealed that observers systematically increased their exploration tendencies when the identity of a material was ambiguous and that this increased movement was associated with higher discrimination accuracy. By independently manipulating head- and hand-based motions, we identified the context-dependent contributions of each modality, revealing that viewpoint changes dominated when multiple objects could be compared simultaneously, whereas object manipulation was more effective when only a single target was available. Moreover, the participants differed in terms of the efficiency of their sampling strategies, and those who employed more informative exploration patterns exhibited both higher accuracy and greater performance gains across different trials. These results demonstrate that material recognition depends on flexible, context-dependent active sensing rather than passive evaluations of static images. Our findings introduce a new framework, according to which material perception emerges from an adaptive perception-action loop, thus highlighting the functional role of exploratory behaviors in complex visual environments. Significance StatementThe task of material perception in natural environments depends not only on the optical properties of surfaces but also on the actions that observers take to reveal informative visual cues. However, most laboratory studies rely on passive viewing, and how humans actively regulate their own movements to reduce perceptual uncertainty remains unknown. On the basis of three virtual-reality experiments, we showed that observers flexibly perform head- and hand-based explorations to enhance the discriminability of visually ambiguous materials. These exploratory strategies were strongly context-dependent and exhibited systematic individual differences that predicted learning-related improvements. Our findings demonstrate that material perception emerges from an adaptive perception-action loop rather than static image analyses, providing a framework for understanding how humans actively acquire diagnostic sensory information in complex environments.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Nomachi, R., Tamura, H., Helgeland, K. A., Morimoto, T., Nakauchi, S., Minami, T.. 2025-12-22. Material perception relies on context-dependent active sensing strategies. https://doi.org/10.64898/2025.12.19.695393

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related preprints

The Unreasonable Effectiveness of Cell Types in Describing Neuronal Physiological Features

Single-cell RNA sequencing (scRNA-seq) captures detailed gene expression profiles at scale, while patch-clamp recordings measure intrinsic neuronal electrophysiological properties. Modeling the relations between these two modalities remains a challenge. Here, we compare how well electrophysiological features can be predicted by traditional transcriptomic cell type classification, representations derived from a foundational model (scGPT) pretrained on large-scale scRNA-seq datasets, ion channel-coding genes, and highly variable genes. Using paired transcriptomic and electrophysiological patch-sequencing data from 495 human neurons from neurosurgical tissue, we find that cluster-level cell type representations consistently outperform highly variable gene selection, ion channel gene selection, and context-enriched scGPT embeddings. Notably, performance varies across model architectures and initializations, and the best results are obtained by combining the outputs of separate cell type and scGPT-based models. Together, these findings suggest that traditional discrete cellular classification is highly effective in predicting physiological features. For maximum performance it can be complemented by pretrained transformer models.

neuroscience↗

A nonlinear inhibition pathway underlying cortical responses to tuned holographic optogenetic perturbations

Optogenetics enables causal manipulation of cortical activity. Perturbation responses can be counterintuitive due to network interactions, making theory essential for predicting them. Existing approaches often rely on linear approximations, which fail for many biologically relevant perturbations. Here we develop a nonlinear theory of responses to holographic perturbations in cell-type-specific recurrent networks with structured connectivity. We fit a nonlinear model to mouse V1 data, which shows cotuned-ensemble suppression: perturbing spatially clustered neurons with similar preferred orientations yields markedly stronger short-range suppression than perturbing untuned ensembles. We show that cotuned-ensemble suppression arises from a feature-tuned, nonlinear inhibition pathway implicating somatostatin-positive (SST) interneurons. The theory predicts that cotuned ensembles suppress parvalbumin-positive (PV) neurons but facilitate SST neurons, and links the degree of cotuned-ensemble suppression or facilitation to the variance of the SST response. This framework identifies mechanisms by which nonlinear inhibition sculpts cortical dynamics and establishes a predictive basis for targeted optogenetic interventions.

neuroscience↗

Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimers disease

The apolipoprotein E {varepsilon}4 (APOE {varepsilon}4) allele is the strongest genetic risk factor for late-onset Alzheimers disease (AD). However, the underlying molecular mechanisms remain unclear. This study included 1691 participants from the Religious Orders Study and Rush Memory and Aging Project (ROSMAP), 1226 participants from the Accelerating Medicines Partnership - Alzheimers Disease (AMP-AD) Diverse Cohorts Study, and 735 participants from the Alzheimers Disease Neuroimaging Initiative (ADNI). To characterise APOE {varepsilon}4 molecular effects, we analysed proteomic data from plasma, cerebrospinal fluid (CSF), and induced pluripotent stem cell (iPSC)-derived astrocytes and neurons, as well as transcriptomic and proteomic data from multiple brain regions. The association of APOE {varepsilon}4 with AD neuropathology was also examined. APOE {varepsilon}4 carriers shared a plasma proteomic signature enriched for immune processes, irrespective of AD diagnosis. A machine learning classifier trained on this signature discriminated APOE {varepsilon}4 carriers from non-carriers in an independent cohort using CSF proteomics. APOE {varepsilon}4 carriage was associated with higher Braak stages and Consortium to Establish a Registry for Alzheimers Disease (CERAD) score. However, only limited APOE {varepsilon}4-associated transcriptomic and proteomic changes were observed in bulk brain tissue, with poor cross-layer concordance. Proteomic analyses of iPSC-derived astrocytes and neurons further revealed cell-type-specific APOE {varepsilon}4-associated changes. APOE {varepsilon}4 is associated with a consistent proteomic signature across plasma and CSF. Its molecular effects in the brain differ across cell types, brain regions and molecular layers. These findings support the need for cell-type-resolved multi-omic studies to elucidate how APOE {varepsilon}4 confers AD risk.

neuroscience↗