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bioRxiv · 10.64898/2025.12.11.693741

CompBio and MIRaS : A Multi-omic Analysis Platform Built on a Memory-Based Intelligence Engine

Head, R. D.·Barve, R. A.·Storer, C. E.·Hoxsie, W. D.·Marcum, C.·McMichael, J. F.·Lalmansingh, J. M.·Smith, B. K.·Johnson, M. R.·Kuster, D. J.
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Abstract

As molecular and cellular technologies have advanced, the need to analyze and interpret the resulting, often vast and multi-modal, data into actionable intelligence has become a rate-limiting factor in scientific advancement. While traditional knowledgebase-pathway tools and LLM-based AI tools both provide a degree of support in data interpretation, both exhibit limitations. Presented here is the CompBio multi-omic analysis platform built upon a novel memory-based intelligence engine, MIRaS. The system is not dependent on human-curated pathway knowledgebases, can perform statistical significance analysis, does not suffer from hallucination, and produces traceable results. Furthermore, substantial effort has been placed in the computer-human knowledge transfer components of the system to enable efficient interaction, interpretation, and learning. The system has undergone years of extensive testing, validation, and evolution in omics-based research with dozens of associated publications verifying its effectiveness. A systematic assessment of CompBio and a detailed description of the MIRaS method are provided.

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Head, R. D., Barve, R. A., Storer, C. E., Hoxsie, W. D., Marcum, C., McMichael, J. F., Lalmansingh, J. M., Smith, B. K., Johnson, M. R., Kuster, D. J.. 2025-12-15. CompBio and MIRaS : A Multi-omic Analysis Platform Built on a Memory-Based Intelligence Engine. https://doi.org/10.64898/2025.12.11.693741

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