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bioRxiv · 10.64898/2025.12.02.691903

Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD⁺ Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma

Dubey, S.·Yu, G.·Aboul-Hosn, R.·Tse, C.·Nathanson, D. A.·Lai, A.·Vossel, K.·Rodriguez, F. J.
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Abstract

While CDKN2A loss is classically associated with cell cycle deregulation through the p16-Cdk4-Rb axis, our findings suggest an additional layer of metabolic vulnerability arising from altered NAD homeostasis in CDKN2A-deleted glioblastoma, revealing a previously unrecognized metabolic-genetic interface for rationally revisiting NAD+ targeting strategies, moving beyond the broad inhibition approaches.

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Dubey, S., Yu, G., Aboul-Hosn, R., Tse, C., Nathanson, D. A., Lai, A., Vossel, K., Rodriguez, F. J.. 2025-12-04. Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD⁺ Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma. https://doi.org/10.64898/2025.12.02.691903

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