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bioRxiv · 10.64898/2025.12.02.691788

A deformable attractor manifold organizes human resting-state brain dynamics

Abstract

Intrinsic brain activity is often described as wandering within a continuous multivariate space, yet the organizing principles that constrain these dynamics remain unclear. Here, we show that spontaneous human brain activity during rest is structured by a deformable attractor manifold. Using large-scale fMRI datasets and a latent dynamical model, we find that cortical activity occupies two reproducible regimes: a low-coherence state with a unimodal latent distribution and a high-coherence state that exhibits bimodality, consistent with transient bistability across association networks. A compact two-parameter energy landscape explains these dynamics, revealing that transitions arise not from switching between discrete states, but from continuous deformation of the manifold that reshapes attractor geometry. Excursions into the bistable regime occur as rapid "jumps", whereas returns follow slow drifts along the manifold, reflecting network-specific timescales. Individuals with greater expression of the bistable regime show higher cognitive fluidity, and manifold parameters differentiate mild cognitive impairment from matched controls. These findings identify an organizing geometric and dynamical principle of resting activity, linking large-scale cortical coordination, cognitive variability, and vulnerability to pathology.

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BibTeXRIS

Athanasiadis, A.-P., Woodman, M., Hashemi, M., Triebkorn, P., Petkoski, S., Jirsa, V.. 2025-12-04. A deformable attractor manifold organizes human resting-state brain dynamics. https://doi.org/10.64898/2025.12.02.691788

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