A resource of targeted mutant mouse lines for 5,061 genes

Birling, M.-C.; Yoshiki, A.; Adams, D. J.; Ayabe, S.; Beaudet, A. L.; Bottomley, J.; Bradley, A.; Brown, S. D. M.; Bürger, A.; Bushell, W.; Chiani, F.; Chin, H.-J. G.; Christou, S.; Codner, G. F.; DeMayo, F. J.; Dickinson, M.; Doe, B.; Donahue, L. R.; Fray, M. D.; Gambadoro, A.; Gao, X.; Gertsenstein, M.; Gomez-Segura, A.; Goodwin, L. O.; Heaney, J. D.; Hérault, Y.; Hrabe de Angelis, M.; Jiang, S.-T.; Justice, M. J.; Kasparek, P.; King, R. E.; Kühn, R.; Lee, H.; Lee, Y. J.; Liu, Z.; Lloyd, K. C. K.; Lorenzo, I.; Mallon, A.-M.; McKerlie, C.; Meehan, T. F.; Newman, S.; Nutter, L. M

doi:10.1101/844092

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bioRxiv · 10.1101/844092

A resource of targeted mutant mouse lines for 5,061 genes

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Abstract

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes from targeted embryonic stem cells on the C57BL/6N genetic background. This includes 2,850 null alleles for which no equivalent mutant mouse line exists, 2,987 novel conditional-ready alleles, and 4,433 novel reporter alleles. This nearly triples the number of genes with reporter alleles and almost doubles the number of conditional alleles available to the scientific community. When combined with more than 30 years of community effort, the total mutant allele mouse resource covers more than half of the genome. The extensively validated collection is archived and distributed through public repositories, facilitating availability to the worldwide biomedical research community, and expanding our understanding of gene function and human disease.

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Birling, M.-C., Yoshiki, A., Adams, D. J., Ayabe, S., Beaudet, A. L., Bottomley, J., Bradley, A., Brown, S. D. M., Bürger, A., Bushell, W., Chiani, F., Chin, H.-J. G., Christou, S., Codner, G. F., DeMayo, F. J., Dickinson, M., Doe, B., Donahue, L. R., Fray, M. D., Gambadoro, A., Gao, X., Gertsenstein, M., Gomez-Segura, A., Goodwin, L. O., Heaney, J. D., Hérault, Y., Hrabe de Angelis, M., Jiang, S.-T., Justice, M. J., Kasparek, P., King, R. E., Kühn, R., Lee, H., Lee, Y. J., Liu, Z., Lloyd, K. C. K., Lorenzo, I., Mallon, A.-M., McKerlie, C., Meehan, T. F., Newman, S., Nutter, L. M. 2019-11-22. A resource of targeted mutant mouse lines for 5,061 genes. https://doi.org/10.1101/844092

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