Meta-analysis of Scandinavian Schizophrenia Exomes

Lescai, F.; Grove, J.; Satterstrom, F. K.; Rees, E.; Bybjerg-Grauholm, J.; Damm Als, T.; Kalinowski, J.; Halager, A.; Singh, T.; Li, Q.; Wang, J.; Walters, J. T.; Owen, M. J.; O'Donovan, M.; Nordentoft, M.; Mortensen, P. B.; Hougaard, D. M.; Werge, T.; Mors, O.; Neale, B.; Daly, M.; Boerglum, A.

doi:10.1101/836957

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bioRxiv · 10.1101/836957

Meta-analysis of Scandinavian Schizophrenia Exomes

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Abstract

Rare genetic variants may play a prominent role in schizophrenia. We report on the to date largest whole exome sequencing study of schizophrenia case-control samples from related populations and combine with other available sequence data, analysing in total 34,084 individuals (14,302 cases). Three genes showed significant association at FDR < 0.10 (SETD1A, TAF13 and MKI67) and gene-set analyses highlighted the involvement of the synaptome and excitatory neurons, and demonstrated shared architecture with high-functioning autism.

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Lescai, F., Grove, J., Satterstrom, F. K., Rees, E., Bybjerg-Grauholm, J., Damm Als, T., Kalinowski, J., Halager, A., Singh, T., Li, Q., Wang, J., Walters, J. T., Owen, M. J., O'Donovan, M., Nordentoft, M., Mortensen, P. B., Hougaard, D. M., Werge, T., Mors, O., Neale, B., Daly, M., Boerglum, A.. 2019-11-09. Meta-analysis of Scandinavian Schizophrenia Exomes. https://doi.org/10.1101/836957

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