Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign

Huang, X.-L.; Skrahin, A.; Lu, P.-X.; Alexandru, S.; Crudu, V.; Astrovko, A.; Skrahina, A.; Taaffe, J.; Harris, M.; Long, A.; Wollenberg, K.; Engle, E.; Hurt, D.; Akhundova, I.; Ismayilov, S.; Mammadbayov, E.; Gadirova, H.; Abuzarov, R.; Seyfaddinova, M.; Avaliani, Z.; Vashakidze, S.; Shubladze, N.; Nanava, U.; Strambu, I.; Zaharia, D.; Muntean, A.; Ghita, E.; Bogdan, M.; Mindru, R.; Spinu, V.; Sora, A.; Ene, C.; Sergueev, E.; Kirichenko, V.; Lapitski, V.; Snezhko, E.; Kovalev,, V.; Tuzikov, A.; Gabrielian, A.; Rosenthal, A.; Tartakovsky, M.; Wang, Y.-X.

doi:10.1101/833954

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bioRxiv · 10.1101/833954

Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign

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Abstract

Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5% of previously treated patients had mdrtb. Extensively drug-resistant TB (xdrtb) has resistance to rifampin and isoniazid, as well as to any member of the quinolone family and at least one of the second line injectable drugs: kanamycin, amikacin and capreomycin. xdrtb accounts for 4-20% of mdrtb. Early detection and targeted treatment are priorities for mdrtb/xdrtb control. The suspicion of mdr/xdr -pulmonary TB (mdrptb or xdrptb) by chest imaging shall suggest intensive diagnostic testing for mdrptb/xdrptb. We hypothesize that multiple nodular consolidation (NC) may serve one of the differentiators for separating dsptb vs mdrptb/xdrptb cases. For this study, mdrptb cases (n=310) and XDR-PTB cases ([xcap]=I58) were from the NIAID TB Portals Program (TBPP) . Drug sensitive pulmonary TB (dsptb) cases were from the TBPP collection (n=112) as well as the Shenzhen Center for Chronic Disease Control (n=111), Shenzhen, China, and we excluded patients with HIV(+) status. Our study shows NC, particularly multiple NCs, is more common in mdrptb than in dsptb, and more common in xdrptb than in mdrptb. For example, 2.24% of dsptb patients, 13.23% of mdrptb patients, and 20.89% of xdrptb patients, respectively, have NCs with diameter >= 10mm equal or more than 2 in number.

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Huang, X.-L., Skrahin, A., Lu, P.-X., Alexandru, S., Crudu, V., Astrovko, A., Skrahina, A., Taaffe, J., Harris, M., Long, A., Wollenberg, K., Engle, E., Hurt, D., Akhundova, I., Ismayilov, S., Mammadbayov, E., Gadirova, H., Abuzarov, R., Seyfaddinova, M., Avaliani, Z., Vashakidze, S., Shubladze, N., Nanava, U., Strambu, I., Zaharia, D., Muntean, A., Ghita, E., Bogdan, M., Mindru, R., Spinu, V., Sora, A., Ene, C., Sergueev, E., Kirichenko, V., Lapitski, V., Snezhko, E., Kovalev,, V., Tuzikov, A., Gabrielian, A., Rosenthal, A., Tartakovsky, M., Wang, Y.-X.. 2019-11-07. Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign. https://doi.org/10.1101/833954

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