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bioRxiv · 10.1101/833889

Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level

Lin, Q.·Helmreich, M.·Schlumm, F.·Li, J.·Robson, D.·Engert, F.·Schier, A.·Noebauer, T.·Vaziri, A.
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Abstract

The neuronal basis of goal-directed behavior requires interaction of multiple separated brain regions. How subcortical regions and their interactions with brain-wide activity are involved in action selection is less understood. We have investigated this question by developing an assay based on whole-brain volumetric calcium imaging using light-field microscopy combined with an operant-conditioning task in larval zebrafish. We find global and recurring dynamics of brain states to exhibit pre-motor bifurcations towards mutually exclusive decision outcomes which arises from a spatially distributed network. Within this network the cerebellum shows a particularly strong pre-motor activity, predictive of both the timing and outcome of behavior up to [~]10 seconds before movement initiation. Furthermore, on the single-trial level, decision directions can be inferred from the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the decision time can be quantitatively predicted by the rate of bi-hemispheric population ramping activity. Our results point towards a cognitive role of the cerebellum and its importance in motor planning.

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Lin, Q., Helmreich, M., Schlumm, F., Li, J., Robson, D., Engert, F., Schier, A., Noebauer, T., Vaziri, A.. 2019-11-11. Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level. https://doi.org/10.1101/833889

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