Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein, H.; Barbosa, J.; Rosa-Justicia, M.; Prades, L.; Morato, A.; Galan, A.; Arino, H.; Martinez-Hernandez, E.; Castro-Fornieles, J.; Dalmau, J.; Compte, A.

doi:10.1101/830471

bioRxiv · 10.1101/830471

Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Stein, H.·Barbosa, J.·Rosa-Justicia, M.·Prades, L.·Morato, A.·Galan, A.·Arino, H.·Martinez-Hernandez, E.·Castro-Fornieles, J.·Dalmau, J.·Compte, A.

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Abstract

We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. We argue that NMDAR-related changes in cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support a disruption of a memory mechanism operating on a longer timescale, such as short-term potentiation.

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Stein, H., Barbosa, J., Rosa-Justicia, M., Prades, L., Morato, A., Galan, A., Arino, H., Martinez-Hernandez, E., Castro-Fornieles, J., Dalmau, J., Compte, A.. 2019-11-20. Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia. https://doi.org/10.1101/830471

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