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bioRxiv · 10.1101/802900

Orbitofrontal-striatal potentiation underlies stimulant induced hyperactivity

Bariselli, S.·Miyazaki, N.·Kravitz, A.
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Abstract

Stimulants are one of the most widely prescribed classes of pharmaceuticals, but it is unclear which brain pathways underlie their therapeutic and adverse actions. Here, with real-time monitoring of circuit plasticity, we demonstrate that psychostimulants strengthen orbitofrontal (OFC) to dorsomedial striatum (DMS) pathway synapses, and increase striatal output in awake mice. In vivo high-frequency stimulation of OFC-DMS pathway blocked stimulant-induced potentiation and the expression of locomotor sensitization, thereby directly linking OFC-DMS plasticity to hyperactivity.

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Bariselli, S., Miyazaki, N., Kravitz, A.. 2019-10-13. Orbitofrontal-striatal potentiation underlies stimulant induced hyperactivity. https://doi.org/10.1101/802900

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