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bioRxiv · 10.1101/802538

A sex difference in the composition of the rodent postsynaptic density

Mastro, T. L.·Preza, A.·Basu, S.·Chattarji, S.·Till, S. M.·Kind, P. C.·Kennedy, M. B.
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Abstract

SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of synGAP in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young synGAP+/- mice. Here we show that a highly significant increase in TARP in the PSDs of young synGAP+/- rodents is present only in females and not in males. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP heterozygosity.

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Mastro, T. L., Preza, A., Basu, S., Chattarji, S., Till, S. M., Kind, P. C., Kennedy, M. B.. 2019-10-12. A sex difference in the composition of the rodent postsynaptic density. https://doi.org/10.1101/802538

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