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bioRxiv · 10.1101/797076

Sporulation environment drives phenotypic variation in the pathogen Aspergillus fumigatus

Kang, S. E.·Momany, M.
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Abstract

Aspergillus fumigatus causes more than 300,000 life-threatening infections annually and is widespread across varied environments with a single colony producing thousands of conidia, genetically-identical dormant spores. Conidia are easily wind-dispersed to new environments where they can germinate and, if inhaled by susceptible hosts, cause disease. Using high-throughput, single-cell analysis we show that germination phenotypes vary among genetically-identical individuals and that the environment of spore production determines the degree of germination heterogeneity.

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Kang, S. E., Momany, M.. 2019-10-08. Sporulation environment drives phenotypic variation in the pathogen Aspergillus fumigatus. https://doi.org/10.1101/797076

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