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bioRxiv · 10.1101/795369

Noise propagation shapes condition-dependent gene expression noise in Escherichia coli

Abstract

Although it is well appreciated that gene expression is inherently noisy and that transcriptional noise is encoded in a promoters sequence, little is known about the variation in transcriptional noise across growth conditions. Using flow cytometry we here quantify transcriptional noise in E. coli genome-wide across 8 growth conditions, and find that noise and gene regulation are intimately coupled. Apart from a growth-rate dependent lower bound on noise, we find that individual promoters show highly condition-dependent noise and that condition-dependent expression noise is shaped by noise propagation from regulators to their targets. A simple model of noise propagation identifies TFs that most contribute to both condition-specific and condition-independent noise propagation. The overall correlation structure of sequence and expression properties of E. coli genes uncovers that genes are organized along two principal axes, with the first axis sorting genes by their mean expression and evolutionary rate of their coding regions, and the second axis sorting genes by their expression noise, the number of regulatory inputs in their promoter, and their expression plasticity.

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BibTeXRIS

Urchueguia, A., Galbusera, L., Bellement-Theroue, G., Julou, T., van Nimwegen, E. J.. 2019-10-07. Noise propagation shapes condition-dependent gene expression noise in Escherichia coli. https://doi.org/10.1101/795369

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