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bioRxiv · 10.1101/794024

B-cell enforced expression of the mouse ortholog of MYD88L265P is responsible for Waldenstrom-like B-cell lymphoma.

Ouk, C.·Roland, L.·Saintamand, A.·Gachard, N.·Thomas, M.·Deveza, M.·Faumont, N.·Feuillard, J.·VINCENT-FABERT, C.
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Abstract

Here, we created a conditional transgenic mouse model with insertion of a sequence coding for both MYD88L252P and the Yellow Fluorescent Protein (YFP) into the rosa26-locus. B-cell specific induction of the transgene constantly led to spleen enlargement with expansion of YFP positive B-cells in 8-12 month-old mice, with a moderate B-cell proliferation increase. Being clonal or oligoclonal, these B-cells exhibited a marked morphological and immunophenotypic lymphoplasmocytic aspect with a plasma cell transcriptomic signature and a serum immunoglobulin M peak. Therefore, continuous activation of MYD88 in mice can lead on its own to a lymphoma close to Waldenstrom Macroglobulinemia.\n\nKey pointB-cell specific enforced expression of MYD88L252P leads to a clonal indolent lymphoplasmocytic B-cell lymphoma with a serum IgM peak.

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Ouk, C., Roland, L., Saintamand, A., Gachard, N., Thomas, M., Deveza, M., Faumont, N., Feuillard, J., VINCENT-FABERT, C.. 2019-10-06. B-cell enforced expression of the mouse ortholog of MYD88L265P is responsible for Waldenstrom-like B-cell lymphoma.. https://doi.org/10.1101/794024

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