Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization

Tang, X.; Kudo, Y.; Baker, J.; LaBonte, S.; Jordan, P.; McKinnie, S.; Guo, J.; Huan, T.; Moore, B.; Edlund, A.

doi:10.1101/755025

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bioRxiv · 10.1101/755025

Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization

Tang, X.·Kudo, Y.·Baker, J.·LaBonte, S.·Jordan, P.·McKinnie, S.·Guo, J.·Huan, T.·Moore, B.·Edlund, A.

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Abstract

Streptococcus mutans is a common constituent of dental plaque and an etiologic agent of dental caries (tooth decay). Here we elucidate a biosynthetic pathway, encoded by globally distributed strains of S. mutans, which produces a series of bioactive small molecules including reutericyclin and two N-acyl tetramic acid analogues active against oral commensal bacteria. This pathway may provide S. mutans with a competitive advantage, promoting dysbiosis and caries pathogenesis.

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Tang, X., Kudo, Y., Baker, J., LaBonte, S., Jordan, P., McKinnie, S., Guo, J., Huan, T., Moore, B., Edlund, A.. 2019-09-04. Cariogenic Streptococcus mutans produces strain-specific antibiotics that impair commensal colonization. https://doi.org/10.1101/755025

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