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bioRxiv · 10.1101/754226

Recruitment orders underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain

Abstract

BackgroundThe oculomotor integrator (OI) in the vertebrate hindbrain transforms eye velocity input into persistent position coding output, which plays a crucial role in retinal image stability. For a mechanistic understanding of the integrator function and eye position control, knowledge about the tuning of the OI and other oculomotor nuclei is needed. Zebrafish are increasingly used to study integrator function and sensorimotor circuits, yet the precise neuronal tuning to motor variables remains uncharacterized.\n\nResultsHere, we recorded cellular calcium signals while evoking monocular and binocular optokinetic eye movements at different slow-phase eye velocities. Our analysis reveals the anatomical distributions of motoneurons and internuclear neurons in the nucleus abducens as well as those of oculomotor neurons in caudally adjacent hindbrain volumes. Each neuron is tuned to eye position and/or velocity to variable extents and is only activated after surpassing particular eye position and velocity thresholds. While the abducens (rhombomeres 5/6) mainly codes for eye position, in rhombomeres 7/8 a velocity-to-position coding gradient exists along the rostro-caudal axis, which likely corresponds to the velocity and position storage mechanisms. Position encoding neurons are recruited at eye position thresholds distributed across the behavioral dynamic range, while velocity encoding neurons have more centered firing thresholds for velocity. In the abducens, neurons coding exclusively for one eye intermingle with neurons coding for both eyes. Many of these binocular neurons are preferentially active during conjugate eye movements, which represents a functional diversification in the final common motor pathway.\n\nConclusionsWe localized and functionally characterized the repertoire of oculomotor neurons in the zebrafish hindbrain. Our findings provide evidence for a mixed but task-specific binocular code and suggest that generation of persistent activity is organized along the rostro-caudal axis in the hindbrain.

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Brysch, C., Leyden, C., Arrenberg, A. B.. 2019-09-04. Recruitment orders underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain. https://doi.org/10.1101/754226

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