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bioRxiv · 10.1101/749937

aMpLiTuDe MoDuLaTeD noise for tinnitus suppression in tonal and noise-like tinnitus

Schoisswohl, S.·Arnds, J.·Schecklmann, M.·Langguth, B.·Schlee, W.·Neff, P.
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Abstract

BackgroundAcoustic stimulation offers a potential treatment approach for tinnitus but also in-sights in its basic mechanisms by short-term tinnitus suppression called residual inhibition (RI). The effects of RI were found to be depending on intensity, length or sound types covering the individual tinnitus characteristics. In patients with tonal tinnitus RI was increased with amplitude modulated (AM) pure tones at the individual tinnitus frequency while the effects of modulated noise sounds have not been systematically researched.\n\nObjectivesThe aim of the present study was to investigate whether in patients with noise-like tinnitus RI can be increased by AM noise-like stimuli according to the individual tinnitus frequency range.\n\nMethodsFor this purpose the individual tinnitus characteristics (noise-like and tonal tinnitus) were assessed via customizable noise-band matching, in order to generate bandpass filtered stimuli according to the individual tinnitus sound (individualized bandpass filtered sounds; IBP). Subsequent, various stimuli differing in bandpass filtering and AM were tested with respect to their potential to induce RI. Patients were acoustically stimulated with seven different types of stimuli for three minutes each and had to rate the loudness of their tinnitus after each stimuli.\n\nResultsResults indicate a general efficacy of noise stimuli for the temporary suppression of tinnitus, but no significant differences between AM and unmodulated IBP. Significantly better effects were observed for the subgroup with noise-like tinnitus (n=14), especially directly after stimulation offset.\n\nConclusionsThe study at hand provides further insights in potential mechanisms behind RI for different types of tinnitus. Beyond that, derived principles may qualify for new or extend current tinnitus sound therapies.

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Schoisswohl, S., Arnds, J., Schecklmann, M., Langguth, B., Schlee, W., Neff, P.. 2019-08-29. aMpLiTuDe MoDuLaTeD noise for tinnitus suppression in tonal and noise-like tinnitus. https://doi.org/10.1101/749937

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