Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals

Sopeyin, A.; Zhou, L.; Li, M.; Barakat, L.; Paintsil, E.

doi:10.1101/742486

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bioRxiv · 10.1101/742486

Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals

Sopeyin, A.·Zhou, L.·Li, M.·Barakat, L.·Paintsil, E.

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Abstract

We investigated the effects of antiretroviral therapy (ART) on cholesterol biosynthesis in a case-control study. mRNA and protein expressions of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and ATP binding cassette transporter A1 (ABCA1) were significantly upregulated in cases (HIV+) compared to controls (HIV-). We observed dysregulation between sterol regulatory element-binding protein 2 (SREBP-2, sensory control) and HMGCR and low-density lipoprotein receptor (LDLR) pathways. Dysregulation of cholesterol biosynthesis genes may predate clinical manifestation of ART-induced lipid abnormalities.

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Sopeyin, A., Zhou, L., Li, M., Barakat, L., Paintsil, E.. 2019-08-21. Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals. https://doi.org/10.1101/742486

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