A neural network model of flexible grasp movement generation

Abstract

One of the primary ways we interact with the world is using our hands. In macaques, the circuit spanning the anterior intraparietal area, the hand area of the ventral premotor cortex, and the primary motor cortex is necessary for transforming visual information into grasping movements. We hypothesized that a recurrent neural network mimicking the multi-area structure of the anatomical circuit and using visual features to generate the required muscle dynamics to grasp objects would explain the neural and computational basis of the grasping circuit. Modular networks with object feature input and sparse inter-module connectivity outperformed other models at explaining neural data and the inter-area relationships present in the biological circuit, despite the absence of neural data during network training. Network dynamics were governed by simple rules, and targeted lesioning of modules produced deficits similar to those observed in lesion studies, providing a potential explanation for how grasping movements are generated.