Automated and rapid self-report of nociception in transgenic mice.

Black, C. J.; Allawala, A. B.; Bloye, K.; Vanent, K. N.; Edhi, M. M.; Saab, C. Y.; Borton, D. A.

doi:10.1101/732305

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bioRxiv · 10.1101/732305

Automated and rapid self-report of nociception in transgenic mice.

Black, C. J.·Allawala, A. B.·Bloye, K.·Vanent, K. N.·Edhi, M. M.·Saab, C. Y.·Borton, D. A.

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Abstract

A time-resolved, conscious report of detected nociceptive stimuli in mice offers an opportunity to examine the relationship between higher order neural circuits and pain perception. We have developed a detection behavior in transgenic mice that leverages temporally precise and cell-specific stimulation to elicit self-reports of nociception. Conscious reporting of peripheral nociceptive input may help identify neural mechanisms that generate pain perception.

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Black, C. J., Allawala, A. B., Bloye, K., Vanent, K. N., Edhi, M. M., Saab, C. Y., Borton, D. A.. 2019-08-12. Automated and rapid self-report of nociception in transgenic mice.. https://doi.org/10.1101/732305

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