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bioRxiv · 10.1101/728568

The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort

Sogunle, E.·Masukume, G.·Nelson, G.
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Abstract

BackgroundObesity is an important public health problem and rates have reached epidemic proportions in many countries. Studies have explored the association between infants delivered by caesarean section and their later life risk of obesity, in many countries outside Africa. As a result of the increasing caesarean section and obesity rates in South Africa, we investigated the association in this country.\n\nMethodsThis was a retrospective analysis of data that were collected from a prospective South African birth cohort (Birth to Twenty Plus), established in 1990. A total of 889 young adults aged 21-24 years were included in the analysis. Multiple logistic regression models were fitted to assess the association between mode of delivery and early adulthood obesity.\n\nResultsOf the 889 young adults, 106 (11.9%) were obese while 72 (8.1%) were delivered by CS; of which 14 (19.4%) were obese. Caesarean section delivery was significantly associated with obesity in young adults after adjusting for potential confounders like gestational age (at delivery), birth weight, sex, maternal age, parity and education (OR 1.99, 95% CI 1.00-3.94, p=0.049).\n\nConclusionThe association of caesarean section with early adulthood obesity should be interpreted with caution because data on certain key confounding factors such as mothers pre-pregnancy body mass index and gestational diabetes were not available. Further research from Africa, with larger sample sizes and databases with useful linking of maternal and infant data, should be conducted.

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Sogunle, E., Masukume, G., Nelson, G.. 2019-08-08. The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort. https://doi.org/10.1101/728568

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