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bioRxiv · 10.1101/717835

Age-related Gene Expression Signatures (AGES) in rats demonstrate early, late, and linear transcriptional changes from multiple tissues

Shavlakadze, T.·Morris, M.·Fang, J.·Wang, S. X.·Zhou, W.·Tse, H. W.·Mondragon-Gonzalez, R.·Roma, G.·Glass, D. J.
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Abstract

In order to understand changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produced a multi-timepoint Age-related Gene Expression Signature (AGES) from liver, kidney, skeletal muscle and hippocampus of rats, comparing 6, 9, 12, 18, 21, 24 and 27-month old animals. We focused on genes that changed in one direction throughout the lifespan of the animal, either early in life (early logistic changes); at mid-age (mid-logistic); late in life (late-logistic); or linearly, throughout the lifespan. The pathways perturbed as a result of chronological age demonstrate organ-specific and more global effects of aging, and point to mechanisms that might be counter-regulated pharmacologically in order to treat age-associated diseases. A small number of genes were regulated by aging in the same manner in every tissue, suggesting they may be more universal markers of aging.

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Shavlakadze, T., Morris, M., Fang, J., Wang, S. X., Zhou, W., Tse, H. W., Mondragon-Gonzalez, R., Roma, G., Glass, D. J.. 2019-07-28. Age-related Gene Expression Signatures (AGES) in rats demonstrate early, late, and linear transcriptional changes from multiple tissues. https://doi.org/10.1101/717835

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