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bioRxiv · 10.1101/710236

RSVdb: A comprehensive database of in vivo mRNA structure

Yu, H.·Zhang, Y.·Sun, Q.·Gao, H.·Tao, S.
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Abstract

RNA fulfills a crucial regulatory role in cells by folding into a complex RNA structure. To date, a chemical compound, dimethyl sulfate (DMS), has been developed to effectively probe the RNA structure at the transcriptome level. We proposed a database, RSVdb (https://taolab.nwafu.edu.cn/rsvdb/), for the browsing and visualization of transcriptome RNA structures. RSVdb, including 626,225 RNAs with validated DMS reactivity from 178 samples in 8 species, supports four main functions: information retrieval, research overview, structure prediction, and resource download. Users can search for species, studies, transcripts and genes of interest; browse the quality control of sequencing data and statistical charts of RNA structure information; preview and perform online prediction of RNA structures in silico and under DMS restraint of different experimental treatments; and download RNA structure data for species and studies. Together, RSVdb provides a reference for RNA structure and will support future research on the function of RNA structure at the transcriptome level.

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Yu, H., Zhang, Y., Sun, Q., Gao, H., Tao, S.. 2019-07-21. RSVdb: A comprehensive database of in vivo mRNA structure. https://doi.org/10.1101/710236

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