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bioRxiv · 10.1101/699710

MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: a translational system referencing a standardized ontology

Rushmore, R. J.·Bouix, S.·Kubicki, M.·Rathi, Y.·Yeterian, E.·Makris, N.
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Abstract

The rhesus macaque is the closest animal model to the human, and investigations into the brain of the rhesus monkey has shed light on the function and organization of the primate brain at a scale and resolution not yet possible in studies of the human brain A cornerstone of the linkage between non-human primate and human studies of the brain is magnetic resonance imaging, which allows for an association to be made between the detailed structural and physiological analysis of the non-human primate and that of the human brain. To further this end, we present a novel parcellation system for the rhesus monkey brain, referred to as the monkey Harvard Oxford Atlas (mHOA) which is based on the human Harvard-Oxford Atlas (HOA) and grounded in an ontological and taxonomic framework. Consistent anatomical features were used to delimit and parcellate brain regions in the macaque, which were then categorized according to functional systems. This system of parcellation will be expanded with advances in technology and like the HOA, will provide a framework upon which the results from other experimental studies (e.g., functional magnetic resonance imaging (fMRI), physiology, connection, graph theory) can be interpreted.

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Rushmore, R. J., Bouix, S., Kubicki, M., Rathi, Y., Yeterian, E., Makris, N.. 2019-07-11. MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: a translational system referencing a standardized ontology. https://doi.org/10.1101/699710

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