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bioRxiv · 10.1101/691295

IDR2D identifies reproducible genomic interactions

Krismer, K.·Guo, Y.·Gifford, D. K.
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Abstract

Chromatin interaction data from protocols such as ChIA-PET, HiChIP, and HiC provide valuable insights into genome organization and gene regulation, but can include spurious interactions that do not reflect underlying genome biology. We introduce a generalization of the Irreproducible Discovery Rate (IDR) method called IDR2D that identifies replicable interactions shared by chromatin interaction experiments. IDR2D provides a principled set of interactions and eliminates artifacts from single experiments. The method is available as a Bioconductor package for the R community, as well as an online service at https://idr2d.mit.edu.

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Krismer, K., Guo, Y., Gifford, D. K.. 2019-07-03. IDR2D identifies reproducible genomic interactions. https://doi.org/10.1101/691295

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