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bioRxiv · 10.1101/668194

Microstimulation of primate neocortex targeting striosomes induces negative decision-making

Amemori, S.·Amemori, K.-i.·Yoshida, T.·Papageorgiou, G. K.·Xu, R.·Shimazu, H.·Desimone, R.·Graybiel, A. M.
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Abstract

Affective judgment and decision-making are strongly modulated by the pregenual anterior cingulate (pACC) and caudal orbitofrontal (cOFC) cortical regions. By combining MRI-guided electrical microstimulation with viral tracing methods in non-human primates, we demonstrate that circumscribed pACC and cOFC microstimulation sites that induce negative decision-making preferentially project to striosomes in the anterior striatum. These results outline a behaviorally important circuit from pACC/cOFC to striosomes causally modulating decision-making under emotional conflict.

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Amemori, S., Amemori, K.-i., Yoshida, T., Papageorgiou, G. K., Xu, R., Shimazu, H., Desimone, R., Graybiel, A. M.. 2019-06-12. Microstimulation of primate neocortex targeting striosomes induces negative decision-making. https://doi.org/10.1101/668194

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