Heterogeneous multi-scale framework for cancer systems models and clinical applications

Ghosh, A.; Radhakrishnan, R.

doi:10.1101/633933

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bioRxiv · 10.1101/633933

Heterogeneous multi-scale framework for cancer systems models and clinical applications

Ghosh, A.·Radhakrishnan, R.

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Abstract

Clinical Cancer models need to incorporate a wide variety of patient data and tumor heterogeneity which requires integration of multiple models. Due to differences in time and length scales of individual processes, such a model integration is a challenging task. Here we have developed an integrated framework combining ErbB receptor mediated Ras-MAPK and PI3K/AKT pathway with p53 mediated DNA damage response pathway. We have applied this in a clinical setting to predict patient specific response of different treatments in cancers of prostate, lung and kidney.

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Ghosh, A., Radhakrishnan, R.. 2019-05-16. Heterogeneous multi-scale framework for cancer systems models and clinical applications. https://doi.org/10.1101/633933

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