Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome

Claesen, J.; Spagnolo, J. B.; Flores Ramos, S.; Kurita, K. L.; Byrd, A. L.; Aksenov, A. A.; Melnik, A. V.; Wong, W. R.; Wang, S.; Hernandez, R. D.; Donia, M. S.; Dorrestein, P. C.; Kong, H. H.; Segre, J. A.; Linington, R. G.; Fischbach, M. A.; Lemon, K. P.

doi:10.1101/594010

bioRxiv · 10.1101/594010

Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome

Claesen, J.·Spagnolo, J. B.·Flores Ramos, S.·Kurita, K. L.·Byrd, A. L.·Aksenov, A. A.·Melnik, A. V.·Wong, W. R.·Wang, S.·Hernandez, R. D.·Donia, M. S.·Dorrestein, P. C.·Kong, H. H.·Segre, J. A.·Linington, R. G.·Fischbach, M. A.·Lemon, K. P.

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Abstract

The composition of the skin microbiome varies widely among individuals sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin. We used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes) that is widely distributed across individuals and skin sites. Experimental characterization of this cluster enabled the identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles showed that cutimycin is an important factor regulating colonization resistance against Staphylococcus species.\n\nOne Sentence SummaryCutimycin, a thiopeptide antibiotic produced by a widespread skin commensal, reduces Staphylococcus colonization of human follicles.

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Claesen, J., Spagnolo, J. B., Flores Ramos, S., Kurita, K. L., Byrd, A. L., Aksenov, A. A., Melnik, A. V., Wong, W. R., Wang, S., Hernandez, R. D., Donia, M. S., Dorrestein, P. C., Kong, H. H., Segre, J. A., Linington, R. G., Fischbach, M. A., Lemon, K. P.. 2019-03-30. Cutibacterium acnes antibiotic production shapes niche competition in the human skin microbiome. https://doi.org/10.1101/594010

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