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bioRxiv · 10.1101/584805

Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb

Lois, C.·Sanchez-Guardado, L.
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Abstract

Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to label neuronal progenitors sparsely and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.

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Lois, C., Sanchez-Guardado, L.. 2019-03-21. Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb. https://doi.org/10.1101/584805

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