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bioRxiv · 10.1101/574962

PHi-C: deciphering Hi-C data into polymer dynamics

Shinkai, S.·Nakagawa, M.·Sugawara, T.·Togashi, Y.·Ochiai, H.·Nakato, R.·Taniguchi, Y.·Onami, S.
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Abstract

Computational modelling methods for Hi-C data have revealed averaged and static features of the 3D genome in cell nuclei. Here, we describe a 4D simulation method, PHi-C (Polymer dynamics deciphered from Hi-C data), that depicts dynamic 3D genome features through polymer modelling. This method allows for demonstrations of dynamic characteristics of genomic loci and chromosomes, as observed in live-cell imaging experiments, and provides physical insights into Hi-C data.

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Shinkai, S., Nakagawa, M., Sugawara, T., Togashi, Y., Ochiai, H., Nakato, R., Taniguchi, Y., Onami, S.. 2019-03-12. PHi-C: deciphering Hi-C data into polymer dynamics. https://doi.org/10.1101/574962

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