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bioRxiv · 10.1101/540443

Quantification of alterations in diffusion measures of white matter integrity associated with healthy aging

Molloy, C. J.·Nugent, S.·Bokde, A. L.
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Abstract

This study aimed to evaluate the linear association of age with diffusion tensor imaging (DTI) measures of white matter such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). We assessed patterns of overlap between linear correlations of age with FA with RD, MD and AD to characterize the process of white matter degeneration observed with ageing. 79 healthy adults aged between 18 and 75 took part in the study. The DTI data were based on 61 directions acquired with a b-value of 2000. There was a statistically significant negative linear correlation of age with FA and AD and a positive linear correlation with RD and MD, and AD. The forceps minor tract showed largest percentage of voxels with an association of age with FA, RD and AD, and the anterior thalamic radiation with MD. We found 5 main patterns of overlap: FA alone (15.95%); FA and RD (31.90%); FA and AD (12.99%); FA, RD and AD (27.37%); FA RD, and MD (6.94%). Patterns of overlap between diffusion measures may reflect underlying biological changes with healthy ageing such as loss of myelination, axonal damage, as well as mild microstructural and chronic white matter impairments. This study may provide information about causes of degeneration in specific regions of the brain, and how this may affect healthy brain functioning in older adults.

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Molloy, C. J., Nugent, S., Bokde, A. L.. 2019-02-04. Quantification of alterations in diffusion measures of white matter integrity associated with healthy aging. https://doi.org/10.1101/540443

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